Anderlik P, Szeri I, Antmann K, Bános Z
Semmelweis OTE Mikrobiológiai Intézete, Közegészségtani.
Acta Pharm Hung. 1995 Jan;65(1):5-8.
In acute toxicity experiments the changes in drug sensitivity and in the rate of bacterial translocation (BT) were investigated in mice treated with immunomodulatory drugs: dianhydrogalactitol (DAG) in doses 20 and 30 mg/kg, chlorpromazine (CPZ) in doses 60 and 75 mg/kg and Mannozym (M) in dose 40 mg/kg for zymosan content. The drugs were used separately or in combination. The sensitivity of mice to immunosuppressive DAG or CPZ was higher in the case of combined treatment, than that of separately treated ones. The rate of BT was also higher in combined treated mice. The pretreatment with M that has immunostimulatory effect, influenced neither the sensitivity of mice to DAG or CPZ, nor the normal very low rate of BT. The present results reinforced the authors' earlier observations, that the effects of immunosuppressive drugs could cumulate and cause more serious damage of the organism. The authors suggest that the increase in drug sensitivity to immunosuppressive agents is in connection with increased rate of BT and effect of endotoxin.
在急性毒性实验中，研究了用免疫调节药物处理的小鼠的药物敏感性变化和细菌移位（BT）率：20和30mg/kg剂量的去水卫矛醇（DAG）、60和75mg/kg剂量的氯丙嗪（CPZ）以及40mg/kg剂量的甘露聚糖酶（M）用于酵母聚糖含量测定。这些药物单独或联合使用。联合治疗时，小鼠对免疫抑制性药物DAG或CPZ的敏感性高于单独治疗组。联合治疗小鼠的BT率也更高。具有免疫刺激作用的M预处理，既不影响小鼠对DAG或CPZ的敏感性，也不影响正常极低的BT率。目前的结果强化了作者早期的观察结果，即免疫抑制药物的作用可能会累积并对机体造成更严重的损害。作者认为，对免疫抑制剂的药物敏感性增加与BT率增加和内毒素作用有关。
