Anderlik P, Antmann K, Bános Z
Institute of Microbiology, Semmelweis University of Medicine, Budapest, Hungary.
Acta Microbiol Immunol Hung. 1998;45(2):257-61.
Following intraperitoneally applied treatment with antilymphocyte serum (ALS) of immunosuppressive effect no bacterial translocation (BT) was observed in mice. The ALS treatment applied in combination with other immunosuppressive agents such as lymphotropic cytostatics as dianhydrogalactitol or chlorpromazine did not increase the mice's drug sensitivity to the used agents. According to our results, ALS can be suitable for combined application with other immunosuppressive agents as it can increase immunosuppression without side-effects such as those induced by bacterial translocation.
经腹腔注射具有免疫抑制作用的抗淋巴细胞血清（ALS）治疗后，未在小鼠中观察到细菌移位（BT）。将ALS与其他免疫抑制剂如亲淋巴细胞性细胞抑制剂二脱水半乳糖醇或氯丙嗪联合应用，并未增加小鼠对所用药物的药物敏感性。根据我们的结果，ALS可适合与其他免疫抑制剂联合应用，因为它可增强免疫抑制作用，而无细菌移位所诱导的诸如那些副作用。
