Anderlik P, Szeri I, Antmann K, Bános Z
Institute of Microbiology, Semmelweis University Medical School, Budapest, Hungary.
Acta Microbiol Immunol Hung. 1995;42(3):261-9.
In acute toxicity experiments changes in drug sensitivity and in the rate of bacterial translocation (BT) were investigated in mice treated with immunomodulatory drugs: dianhydrogalactitol (DAG) in doses 20 and 30 mg/kg, chlorpromazine (CPZ) in doses 60 and 75 mg/kg and Mannozym (M) in dose equivalent to 40 mg per kg zymosan. The drugs were used separately or in combination. The sensitivity of mice to immunosuppressive DAG or CPZ was higher in the case of combined treatment than that of separately treated ones. The rate of BT was also higher in mice receiving combined treatment. Pretreatment with M exerting an immunostimulatory effect, influenced neither the sensitivity of mice to DAG or CPZ nor the very low normal rate of BT. The present results reinforced the authors' earlier observations that the effects of immunosuppressive drugs cumulated in and caused more serious damage of the organism. The increase in drug sensitivity to immunosuppressive agents may be connected with an increased rate of BT and effect of endotoxin.
在急性毒性实验中，研究了用免疫调节药物处理的小鼠的药物敏感性变化和细菌移位（BT）速率：剂量为20和30mg/kg的双去水半乳糖醇（DAG）、剂量为60和75mg/kg的氯丙嗪（CPZ）以及剂量相当于每千克40mg酵母聚糖的甘露聚糖酶（M）。这些药物单独使用或联合使用。联合治疗时小鼠对免疫抑制性DAG或CPZ的敏感性高于单独治疗组。联合治疗的小鼠中BT速率也更高。发挥免疫刺激作用的M预处理既不影响小鼠对DAG或CPZ的敏感性，也不影响极低的正常BT速率。目前的结果强化了作者早期的观察结果，即免疫抑制药物的作用在体内累积并对机体造成更严重的损害。对免疫抑制剂药物敏感性的增加可能与BT速率增加和内毒素的作用有关。
