Toghill P J, Green S
J Clin Pathol. 1975 Jan;28(1):8-11. doi: 10.1136/jcp.28.1.8.
The haematological role of the spleen has been investigated in a series of 22 patients with active chronic hepatitis. Severe pancytopenia occurred in one patient after three years of steroid therapy and this episode was associated with an increase in spleen size and a high splenic index of red cell destruction. Although the spleen was usually enlarged in the remainder of treated and untreated patients no others showed increased splenic haemolysis. The red cell survival was slightly reduced in most patients but splenic pooling of red cells and expansion of the plasma volume did not significantly reduce the haematocrit level. No consistent haematological differences were detected between the untreated and the treated patients.
对22例活动性慢性肝炎患者进行了一系列研究，以探讨脾脏在血液学方面的作用。1例患者在接受三年类固醇治疗后出现严重全血细胞减少，这一情况与脾脏肿大及红细胞破坏的高脾脏指数相关。尽管在其余接受治疗和未接受治疗的患者中脾脏通常肿大，但没有其他患者出现脾脏溶血增加的情况。大多数患者的红细胞存活时间略有缩短，但红细胞在脾脏的蓄积和血浆容量的增加并未显著降低血细胞比容水平。未治疗患者和治疗患者之间未发现一致的血液学差异。
