Zhang B, Lewis S M
Br J Haematol. 1987 May;66(1):97-102. doi: 10.1111/j.1365-2141.1987.tb06896.x.
A method was established for estimation of plasma volume and splenic plasma pool by quantitative scanning using 113mIn labelled transferrin (TF). The method was used in 12 patients with various haematological disorders and degrees of splenomegaly. 113mIn-TF consistently gave about 6% over-estimation of plasma volume by comparison with the standard 125I HSA method. The splenic plasma pool ranged from 1.2% to 11.4% of the total plasma volume. By concurrent measurement of splenic red cell pool the splenic haematocrit (SHct) was obtained: mean 0.51, SD 0.08; the SHct/PCV ratio was 1.21 (SD 0.31) and the SHct/body Hct ratio was 1.30 (SD 0.30). SHct was independent of PCV and body Hct but there was a trend to a lower SHct in cases where splenomegaly was more marked. Direct measurement of splenic plasma pool may help to elucidate the cause of increased total plasma volume in such patients.
建立了一种使用113mIn标记转铁蛋白（TF）通过定量扫描估算血浆容量和脾血浆池的方法。该方法应用于12例患有各种血液系统疾病和不同程度脾肿大的患者。与标准的125I HSA方法相比，113mIn-TF始终使血浆容量高估约6%。脾血浆池占总血浆容量的1.2%至11.4%。通过同时测量脾红细胞池获得脾血细胞比容（SHct）：平均值为0.51，标准差为0.08；SHct/PCV比值为1.21（标准差为0.31），SHct/体血细胞比容比值为1.30（标准差为0.30）。SHct与PCV和体血细胞比容无关，但在脾肿大更明显的病例中，SHct有降低的趋势。直接测量脾血浆池可能有助于阐明此类患者总血浆容量增加的原因。
