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[局部麻醉药浸润手术切口用于腰椎间盘突出症手术患者术后镇痛。罗哌卡因与布比卡因的对比研究]

[Infiltration of the surgical wound with local anesthetic for postoperative analgesia in patients operated on for lumbar disc herniation. Comparative study of ropivacaine and bupivacaine].

作者信息

Hernández-Palazón J, Tortosa Serrano J A, Burguillos López S, Molero Molero E

机构信息

Servicio de Anestesiología y Reanimación, Hospital Universitario Virgen de la Arrixaca, Murcia.

出版信息

Rev Esp Anestesiol Reanim. 2001 Jan;48(1):17-20.

Abstract

OBJECTIVE

To assess and compare the analgesic efficacy of infiltrating the wound with ropivacaine or bupivacaine for postoperative pain after lumbar disk repair.

PATIENTS AND METHODS

A prospective, randomized double blind study of 45 patients undergoing elective surgery for herniated lumbar disk repair under general anesthesia. Before the surgical wound was closed, the paraspinal musculature and subcutaneous tissue were infused with 30 ml of 0.25% ropivacaine in group I (n = 15), 30 ml of 0.25% bupivacaine in group II (n = 15) or 30 ml of saline solution in group III (n = 15). Ketorolac for supplementary postoperative analgesia was made available through a patient-controlled intravenous system. We analyzed the degree of pain on a visual analog scale and level of pain relief on a simple descriptive scale.

RESULTS

No significant differences in demographic data, duration of surgery or amount of intraoperative fentanyl administered were observed among the groups. Mean time until the first request for analgesia was significantly longer in group II than in either groups I or III (164 +/- 53 min versus 68 +/- 31 and 38 +/- 14 min, respectively). Significantly less ketorolac was used in groups I and II than in group III (58 +/- 20 and 59 +/- 21 mg versus 118 +/- 32 mg). The mean scores on the visual analog scale were similar in all three groups.

CONCLUSIONS

In this study, infiltration of the surgical wound with 0.25% bupivacaine or 0.25% ropivacaine was similarly effective for treatment of pain after lumbar disk laminectomy.

摘要

目的

评估并比较罗哌卡因或布比卡因伤口浸润用于腰椎间盘修复术后疼痛的镇痛效果。

患者与方法

一项前瞻性、随机双盲研究,纳入45例在全身麻醉下接受择期腰椎间盘突出症修复手术的患者。在手术切口关闭前,I组(n = 15)的椎旁肌肉组织和皮下组织注入30 ml 0.25%罗哌卡因,II组(n = 15)注入30 ml 0.25%布比卡因,III组(n = 15)注入30 ml生理盐水。通过患者自控静脉系统提供酮咯酸用于术后补充镇痛。我们采用视觉模拟量表分析疼痛程度,采用简单描述性量表分析疼痛缓解程度。

结果

各组间在人口统计学数据、手术时长或术中芬太尼用量方面未观察到显著差异。II组首次要求镇痛的平均时间显著长于I组和III组(分别为164±53分钟、68±31分钟和38±14分钟)。I组和II组使用的酮咯酸显著少于III组(分别为58±20毫克、59±21毫克和118±32毫克)。三组视觉模拟量表的平均评分相似。

结论

在本研究中,0.25%布比卡因或0.25%罗哌卡因伤口浸润用于腰椎间盘切除术后疼痛治疗的效果相似。

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