Moryś Joanna M, Bobek-Billewicz Barbara, Dziewiatkowski Jerzy, Ratajczak Ilona, Pankiewicz Piotr, Narkiewicz Olgierd, Moryś Janusz
Department of Anatomy and Neurobiology, Medical University, Gdansk, Poland.
Folia Morphol (Warsz). 2003 Nov;62(4):347-52.
Depression is one of the most common psychiatric disorders and is associated with considerable morbidity. In recent years structural-imaging technology has provided an opportunity to examine the brain anatomy in patients with the psychiatric illness. 10 patients of various ages and, as the control group, 16 healthy subjects were examined using the MRI method of neuroimaging. The volumes of the following structures were evaluated in the right and left hemispheres: the superior temporal gyrus, the basolateral temporal area (the region including middle temporal gyrus, inferior temporal gyrus and fusiform gyrus), the parahippocampal gyrus, the hippocampal head, the amygdaloid body and the lateral ventricle. The significant difference between the control group and the group with depression concerned the volume of the temporal horn of the lateral ventricle of both hemispheres. In depressed patients the left temporal horn was 49.8% and the right 38.4% larger in comparison with the control group. In the control group there were significant differences between the left and right hemispheres in the volume of all the structures studied, whereas in the group with depression these difference in volume between the hemispheres concerned only the amygdaloid body and the lateral ventricle.
抑郁症是最常见的精神疾病之一，且与相当高的发病率相关。近年来，结构成像技术为研究患有精神疾病的患者的脑解剖结构提供了契机。采用神经成像的MRI方法对10名不同年龄段的患者以及作为对照组的16名健康受试者进行了检查。在左右半球评估了以下结构的体积：颞上回、颞叶基底外侧区（包括颞中回、颞下回和梭状回的区域）、海马旁回、海马头部、杏仁体和侧脑室。对照组与抑郁症组之间的显著差异涉及双侧半球侧脑室颞角的体积。与对照组相比，抑郁症患者的左侧颞角大49.8%，右侧大38.4%。在对照组中，所研究的所有结构的体积在左右半球之间存在显著差异，而在抑郁症组中，半球之间的这些体积差异仅涉及杏仁体和侧脑室。
