Eschenbach D A, Patton D L, Hooton T M, Meier A S, Stapleton A, Aura J, Agnew K
Dept. of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195-6460, USA.
J Infect Dis. 2001 Mar 15;183(6):913-8. doi: 10.1086/319251. Epub 2001 Feb 21.
Effects of a single episode of intercourse on vaginal flora and epithelium were examined in subjects randomly assigned to groups that used no condom or lubricated nonspermicide condoms. Subjects were evaluated at visits before (1 month and 1-2 days) and after (8-12 h, 2-3 days, and 6-8 days) an index episode of sexual intercourse. The 22 subjects who used no condoms had significantly more Escherichia coli and a high concentration (> or =10(5) cfu/mL) of E. coli in the vagina (both, P<.001) and urine (all <10(5) cfu/mL; P=.004) at visit 3 than at visits 1 and 2. The 20 subjects who used condoms had a trend toward more vaginal E. coli (P=.06) and a significant increase in other enteric gram-negative rods (P=.001) after intercourse. Intercourse was not associated with gross, colposcopic, or histologic vaginal epithelial abnormalities.
在随机分配至不使用避孕套组或使用润滑无杀精剂避孕套组的受试者中，研究了单次性交对阴道菌群和上皮的影响。在索引性交事件之前（1个月以及1 - 2天）和之后（8 - 12小时、2 - 3天以及6 - 8天）的访视中对受试者进行评估。与在第1次和第2次访视时相比，在第3次访视时，22名不使用避孕套的受试者阴道中大肠杆菌显著更多且大肠杆菌浓度较高（≥10⁵ cfu/mL）（两者，P<0.001），尿液中大肠杆菌浓度均<10⁵ cfu/mL（P = 0.004）。20名使用避孕套的受试者性交后阴道大肠杆菌有增多趋势（P = 0.06），其他肠道革兰氏阴性杆菌显著增加（P = 0.001）。性交与肉眼可见、阴道镜或组织学检查的阴道上皮异常无关。
