Henning K J, Hall E L, Dwyer D M, Billmann L, Schuchat A, Johnson J A, Harrison L H
Epidemiology and Disease Control Program, Maryland Department of Health and Mental Hygiene, Baltimore, MD, USA.
J Infect Dis. 2001 Apr 1;183(7):1138-42. doi: 10.1086/319278. Epub 2001 Mar 1.
Between 1991 and 1995, among 999 nonpregnant adult Maryland residents with group B Streptococcus (GBS) isolated from a normally sterile site, 84 resided in nursing homes (NHs). The age-adjusted annual incidence of GBS infection (per 100,000 population) among those > or = 65 years old was 72.3 for NH residents and 17.5 for community residents (relative risk, 4.1; P < 0.001). Thirty-four case patients resided in 11 NHs with > or = 2 cases; 1 NH had 8 case patients within 22 months. Six of 8 case patients from 3 NHs had serotype V GBS. Molecular subtyping of several isolates identified 2 case patients in 1 NH with identical subtype patterns. NH residents have a markedly higher incidence of invasive GBS than do community residents > or = 65 years old and may serve as a target group for immunization when GBS vaccines become available. Further evaluation of intra-NH transmission of GBS is warranted.
1991年至1995年间，在999名从正常无菌部位分离出B族链球菌（GBS）的非妊娠成年马里兰州居民中，有84人住在养老院（NHs）。65岁及以上人群中，NH居民GBS感染的年龄调整年发病率（每10万人）为72.3，社区居民为17.5（相对风险，4.1；P<0.001）。34例患者住在11家有2例及以上病例的NHs中；1家NH在22个月内有8例患者。来自3家NHs的8例患者中有6例为V型GBS血清型。对多个分离株的分子亚型分析发现，1家NH中有2例患者具有相同的亚型模式。NH居民侵袭性GBS的发病率明显高于65岁及以上的社区居民，当GBS疫苗可用时，NH居民可能成为免疫接种的目标人群。有必要对NHs内GBS的传播进行进一步评估。
