微小棒状杆菌免疫激活后小鼠脑中细胞因子的表达
Cytokine expression in the mouse brain in response to immune activation by Corynebacterium parvum.
作者信息
Sheng W S, Hu S, Ding J M, Chao C C, Peterson P K
机构信息
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, and the University of Minnesota Medical School, NeuroImmunology Lab D-305, 914 South 8th St., Minneapolis, MN 55404, USA.
出版信息
Clin Diagn Lab Immunol. 2001 Mar;8(2):446-8. doi: 10.1128/CDLI.8.2.446-448.2001.
Abstract
Cytokine expression in the brain has been suggested to mediate various sickness behaviors. Here we report that intraperitoneal injection of a Corynebacterium parvum antigen in C57BL/6 mice was followed by prolonged upregulation of cytokines in the cerebral cortex and subcortical structures in a time course that coincided with reduced spontaneous running activity.
摘要
已有研究表明，大脑中的细胞因子表达介导了各种疾病行为。在此我们报告，给C57BL/6小鼠腹腔注射微小棒状杆菌抗原后，大脑皮层和皮层下结构中的细胞因子会出现长时间上调，其时间进程与自发跑步活动减少相一致。
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