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由CD4 T淋巴细胞介导的鼠γ疱疹病毒68阳性B细胞淋巴瘤的消退

Regression of a murine gammaherpesvirus 68-positive b-cell lymphoma mediated by CD4 T lymphocytes.

作者信息

Robertson K A, Usherwood E J, Nash A A

机构信息

Department of Veterinary Pathology, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom.

出版信息

J Virol. 2001 Apr;75(7):3480-2. doi: 10.1128/JVI.75.7.3480-3482.2001.

DOI:10.1128/JVI.75.7.3480-3482.2001
PMID:11238875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC114142/
Abstract

Murine gammaherpesvirus 68-infected S11 cells were injected subcutaneously into nude mice. Adoptively transferred restimulated lymphocytes consistently elicited the regression of S11 tumors. CD4 T lymphocytes were most effective in preventing tumor formation, and immunohistochemistry highlighted populations of CD4 T cells in regressing tumors.

摘要

将感染鼠γ疱疹病毒68的S11细胞皮下注射到裸鼠体内。过继转移的经再刺激淋巴细胞持续引发S11肿瘤消退。CD4 T淋巴细胞在预防肿瘤形成方面最为有效，免疫组织化学显示消退肿瘤中有CD4 T细胞群体。

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