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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes.

作者信息

Saltiel A R

机构信息

Department of Medicine, Life Sciences Institute, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

出版信息

Cell. 2001 Feb 23;104(4):517-29. doi: 10.1016/s0092-8674(01)00239-2.

DOI:10.1016/s0092-8674(01)00239-2
PMID:11239409
Abstract
摘要

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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes.2型糖尿病分子发病机制与治疗的新视角
Cell. 2001 Feb 23;104(4):517-29. doi: 10.1016/s0092-8674(01)00239-2.
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[Molecular pathogenesis of type 2 diabetes mellitus].[2型糖尿病的分子发病机制]
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Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: is a divorce possible?胰岛素缺乏与胰岛素抵抗在非胰岛素依赖型糖尿病发病机制中的作用:二者能否分离?
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Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes.确定肥胖、胰岛素抵抗与β细胞功能之间的联系:脂肪细胞衍生细胞因子在2型糖尿病发病机制中的潜在作用。
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Disruption of IRS-2 causes type 2 diabetes in mice.胰岛素受体底物-2(IRS-2)功能紊乱会导致小鼠患2型糖尿病。
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Insulin signaling in health and disease.健康与疾病中的胰岛素信号传导。
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Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models.在动物模型中,营养诱导的胰岛素抵抗和受体缺陷导致β细胞功能衰竭。
Ann N Y Acad Sci. 1999 Nov 18;892:223-46. doi: 10.1111/j.1749-6632.1999.tb07798.x.
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Causation of type 2 diabetes -- the Gordian knot unravels.2型糖尿病的病因——难解之结被解开。
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