Steiner M J, Taylor D J, Feldblum P J, Wheeless A J
Family Health International, Research Triangle Park, NC 27709, USA.
Contraception. 2000 Dec;62(6):315-9. doi: 10.1016/s0010-7824(00)00185-2.
To evaluate the contraceptive effectiveness of male latex condoms, we assembled a cohort of 300 women relying on male latex condoms for contraception and followed them prospectively for one menstrual cycle. None of the 234 women who completed the study and reported at least one act of intercourse conceived (one cycle pregnancy rate 0%; 95% CI 0%--2%). Given the pattern of intercourse during the cycle and 3 different sets of conception probabilities for different days of the cycle, we would have expected between 32 and 36 pregnancies if no condoms had been used. Thus, the prevented fraction due to condom use (effectiveness) is 100% and the lower bounds of the 95% CI are between 89% and 90%. For this cohort, male latex condoms were an effective method of contraception. This cost-efficient approach of evaluating contraceptive effectiveness shows promise for post-marketing studies.
为评估男性乳胶避孕套的避孕效果，我们招募了300名依靠男性乳胶避孕套避孕的女性，并对她们进行了为期一个月经周期的前瞻性跟踪。在完成研究并报告至少有一次性交的234名女性中，无人怀孕（一个周期的妊娠率为0%；95%置信区间为0% - 2%）。考虑到月经周期中的性交模式以及周期不同日期的3组不同受孕概率，如果未使用避孕套，我们预计会有32至36例怀孕。因此，使用避孕套导致的预防率（有效性）为100%，95%置信区间的下限在89%至90%之间。对于该队列而言，男性乳胶避孕套是一种有效的避孕方法。这种评估避孕效果的经济高效方法在上市后研究中显示出前景。
