Jaroszeski M J, Coppola D, Pottinger C, Benson K, Gilbert R A, Heller R
Department of Surgery, MDC Box 16, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612-4799, USA.
Eur J Cancer. 2001 Feb;37(3):422-30. doi: 10.1016/s0959-8049(00)00412-3.
The effectiveness of antineoplastic agents has been augmented by applying pulsed electric fields directly to tumours after the administration of the drug. This treatment, known as electrochemotherapy (ECT), has been successful for cutaneous malignancies in animal models and in recent clinical trials. This study was aimed at investigating the applicability of ECT in a surgical setting for hepatocellular carcinomas induced in the livers of rats. Established tumours were injected with bleomycin, and electric pulses were then administered locally. Animals were followed based on tumour volumes and histological samples. Dose response data were obtained for both electric field intensity and bleomycin. Complete response rates for animals treated with electrochemotherapy ranged from 26.67% to 93.33 and were durable. In contrast, tumours that received no treatment, pulses only or drug only responded minimally. This supports the feasibility of using a ECT as a modality for treating hepatocellular carcinoma.
在给予药物后，通过将脉冲电场直接施加于肿瘤，抗肿瘤药物的疗效得到了增强。这种治疗方法称为电化学疗法（ECT），在动物模型和最近的临床试验中，对皮肤恶性肿瘤已取得成功。本研究旨在探讨ECT在手术环境中对大鼠肝脏诱导产生的肝细胞癌的适用性。向已形成的肿瘤注射博来霉素，然后局部施加电脉冲。根据肿瘤体积和组织学样本对动物进行跟踪观察。获得了电场强度和博来霉素的剂量反应数据。接受电化学疗法治疗的动物的完全缓解率在26.67%至93.33%之间，且疗效持久。相比之下，未接受治疗、仅接受脉冲或仅接受药物治疗的肿瘤反应极小。这支持了将ECT用作治疗肝细胞癌方法的可行性。
