Orme I M, McMurray D N, Belisle J T
Mycobacteria Research Laboratories, Dept of Microbiology, Colorado State University, Fort Collins, CO 80523, USA.
Trends Microbiol. 2001 Mar;9(3):115-8. doi: 10.1016/s0966-842x(00)01949-1.
Recent years have seen a renewed effort to develop new vaccines against tuberculosis. As a result, several promising avenues of research have developed, including the production of recombinant vaccines, auxotrophic vaccines, DNA vaccines and subunit vaccines. In this article we briefly review this work, as well as consider the pros and cons of the animal models needed to test these new vaccines. Screening to date has been carried out in mouse and guinea pig models, which have been used to obtain basic information such as the effect of the vaccine on bacterial load, and whether the vaccine can prevent or reduce lung pathology. The results to date lead us to be optimistic that new candidate vaccines could soon be considered for evaluation in clinical trials.
近年来，人们为研发新型抗结核疫苗做出了新的努力。因此，出现了几个有前景的研究方向，包括重组疫苗、营养缺陷型疫苗、DNA疫苗和亚单位疫苗的生产。在本文中，我们简要回顾这项工作，并考量测试这些新型疫苗所需动物模型的优缺点。迄今为止，筛选工作已在小鼠和豚鼠模型中开展，这些模型已用于获取诸如疫苗对细菌载量的影响以及疫苗是否能预防或减轻肺部病变等基本信息。迄今为止的结果让我们乐观地认为，新的候选疫苗可能很快会被考虑用于临床试验评估。
