Eichler J, Moll R
Department of Life Sciences, Ben Gurion University, PO Box 653, Beersheva 84105, Israel.
Trends Microbiol. 2001 Mar;9(3):130-6. doi: 10.1016/s0966-842x(01)01954-0.
It is becoming increasingly clear that similarities exist in the manner in which extracytoplasmic proteins are targeted to complexes responsible for translocating these proteins across membranes in each of the three domains of life. In Eukarya and Bacteria, the signal recognition particle (SRP) directs nascent polypeptides to membrane-embedded translocation sites. In Archaea, the SRP protein targeting pathway apparently represents an intermediate between the bacterial and eukaryal systems. Understanding the archaeal SRP pathway could therefore reveal universal aspects of targeting not detected in current comparisons of the eukaryal and bacterial systems while possibly identifying aspects of the process either not previously reported or unique to Archaea.
越来越明显的是，在生命的三个域中，胞外蛋白靶向负责将这些蛋白跨膜转运的复合物的方式存在相似性。在真核生物和细菌中，信号识别颗粒（SRP）将新生多肽导向膜嵌入的转运位点。在古菌中，SRP蛋白靶向途径显然代表了细菌和真核生物系统之间的一种中间形式。因此，了解古菌的SRP途径可能会揭示在当前真核生物和细菌系统比较中未检测到的靶向普遍方面，同时可能识别该过程中以前未报道过的或古菌特有的方面。
