Miller G D, Frost R, Olive J
Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina 27109, USA.
Nutrition. 2001 Feb;17(2):105-11. doi: 10.1016/s0899-9007(00)00511-6.
The purpose of this study was to examine the relation of leptin to metabolic and dietary factors in college-age adults. Young adult women and men (n = 32) were recruited and underwent testing for measurement of body mass index, body composition, peak oxygen consumption (VO2peak), dietary intake, and plasma levels of leptin and insulin. Ln leptin was significantly greater for women than for men (2.1 versus 1.2 ng/mL, respectively). This difference remained significant even after adjusting ln leptin for fat mass and fat-free mass as covariates in separate analyses. VO2peak was higher for men than for women and this remained significant after adjustment for differences in fat-free mass and total body mass. Significant correlations were found between ln leptin and indicators of fat mass in women and men, with higher correlations for similar variables observed in men (r = 0.548, 0.674, and 0.732 for body mass index, percentage of body fat, and fat mass [kg] for women, respectively, and r = 0.740, 0.888, 0.858 for body mass index, percentage of body fat, and fat mass [kg] for men, respectively). Ln leptin showed a significant inverse relationship with VO2peak (r = -0.751) in men only. After adjusting ln leptin for body fat mass using partial correlations, ln leptin was not significantly associated with any of the measured variables. Alternatively, after normalization of ln leptin using fat mass as the divisor, a less adequate statistical analysis method, men showed statistical significant correlations between ln leptin and dietary intake and VO2peak. Although plasma leptin values were higher in women, stronger associations were evident for men than for women between leptin and metabolic and dietary factors.
本研究的目的是探讨瘦素与大学年龄成年人的代谢和饮食因素之间的关系。招募了年轻成年女性和男性（n = 32），并对其进行了测试，以测量体重指数、身体成分、峰值耗氧量（VO2peak）、饮食摄入量以及瘦素和胰岛素的血浆水平。女性的瘦素ln值显著高于男性（分别为2.1与1.2 ng/mL）。即使在分别将瘦素ln值针对脂肪量和去脂体重作为协变量进行调整后，这种差异仍然显著。男性的VO2peak高于女性，并且在针对去脂体重和总体重差异进行调整后，这一差异仍然显著。在女性和男性中，瘦素ln值与脂肪量指标之间存在显著相关性，男性中相似变量间的相关性更高（女性的体重指数、体脂百分比和脂肪量[kg]的r值分别为0.548、0.674和0.732，男性的体重指数、体脂百分比和脂肪量[kg]的r值分别为0.740、0.888、0.858）。仅在男性中，瘦素ln值与VO2peak呈显著负相关（r = -0.751）。使用偏相关将瘦素ln值针对体脂肪量进行调整后，瘦素ln值与任何测量变量均无显著关联。或者，在使用脂肪量作为除数对瘦素ln值进行归一化后（一种不太合适的统计分析方法），男性的瘦素ln值与饮食摄入量和VO2peak之间存在统计学显著相关性。尽管女性的血浆瘦素值较高，但瘦素与代谢和饮食因素之间的关联在男性中比在女性中更明显。
