[三种噻吗洛尔制剂眼部耐受性的比较研究：防腐剂对眼部耐受性的影响]
[A comparative study of the ocular tolerance of 3 timolol-based preparations: the influence of preservatives on ocular tolerance].
作者信息
Furrer P, Berger J, Mayer J M, Gurny R
机构信息
Section de Pharmacie, Institut de Chimie Thérapeutique, Université de Lausanne, CH-1015 Lausanne, Suisse.
出版信息
J Fr Ophtalmol. 2001 Jan;24(1):13-9.
PURPOSE
Ophthalmic preparations can cause toxic ocular reactions, often associated with the use of preservatives. The aim of this study was to compare the ocular tolerance of three ophthalmic preparations based on timolol: a preservative free ophthalmic preparation (Timabak) and two other commercially available preserved preparations (Timoptol) and Timoptol LP).
METHODS
The effect of repeatedly instilling eye drops for 28 days on rabbit eyes was assessed in vivo by mean of a confocal laser scanning ophthalmoscope. The corneal microlesions were selectively marked by fluorescein.
RESULTS AND CONCLUSION
The overall results show the good ocular tolerance of the three tested products. However, a closer comparison between the products brought out differences in the extent of lesions among the tested products depending on their composition. Indeed the preservative free eye drops appeared better tolerated than the two preserved preparations.
目的
眼科制剂可引起眼部毒性反应，这通常与防腐剂的使用有关。本研究的目的是比较三种基于噻吗洛尔的眼科制剂的眼耐受性：一种无防腐剂的眼科制剂（Timabak）以及另外两种市售的含防腐剂制剂（噻吗心安和噻吗心安LP）。
方法
通过共聚焦激光扫描检眼镜在体内评估连续28天给兔眼滴注眼药水的效果。用荧光素对角膜微损伤进行选择性标记。
结果与结论
总体结果显示这三种受试产品具有良好的眼耐受性。然而，对这些产品进行更细致的比较后发现，受试产品之间根据其成分不同，损伤程度存在差异。事实上，无防腐剂的眼药水似乎比两种含防腐剂的制剂耐受性更好。
Zotero 插件