Martínez-Frías M L
ECEMC, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
Am J Med Genet. 2001 Mar 1;99(2):142-6. doi: 10.1002/1096-8628(2000)9999:999<00::aid-ajmg1139>3.0.co;2-z.
There are very few publications on the possible relationship between maternal diabetes and infants presenting heterotaxia-asymmetry defects. In mice, there is a relationship between maternal diabetes and heterotaxia, although this is influenced by the fetal genotype. An epidemiological analysis of heterotaxia-asymmetry in children born to diabetic mothers (diabetes mellitus or gestational diabetes) is presented here. The analysis is based in the case-control study of the ECEMC database. However, due to the very small sample size for each type of study of heterotaxia-asymmetry alterations, up to 10 control infants for each case were selected. Although the sample size is small, the results suggest that only maternal diabetes mellitus significantly increases the risk for transposition of great vessels (OR=61.87; CI:7.36-519.82), and transposition of viscera (OR=24.82; CI;1.84-335.44).
关于母体糖尿病与出现内脏异位-不对称缺陷的婴儿之间可能存在的关系，相关出版物非常少。在小鼠中，母体糖尿病与内脏异位之间存在关联，尽管这会受到胎儿基因型的影响。本文呈现了对糖尿病母亲（糖尿病或妊娠期糖尿病）所生儿童的内脏异位-不对称情况的一项流行病学分析。该分析基于欧洲先天性心脏病监测协会（ECEMC）数据库的病例对照研究。然而，由于每种内脏异位-不对称改变类型的研究样本量非常小，所以为每个病例最多选取了10名对照婴儿。尽管样本量较小，但结果表明，只有母体糖尿病会显著增加大动脉转位（比值比[OR]=61.87；可信区间[CI]：7.36 - 519.82）和内脏转位（OR=24.82；CI：1.84 - 335.44）的风险。
