Agren J J, Tvrzicka E, Nenonen M T, Helve T, Hänninen O
Department of Physiology, University of Kuopio, PO Box 1627, SF-70211 Kuopio, Finland.
Br J Nutr. 2001 Feb;85(2):137-9. doi: 10.1079/bjn2000234.
The effects of a strict uncooked vegan diet on serum lipid and sterol concentrations were studied in patients with rheumatoid arthritis. The subjects were randomized into a vegan diet group (n 16), who consumed a vegan diet for 2-3 months, or into a control group (n 13), who continued their usual omnivorous diets. Serum total and LDL-cholesterol and -phospholipid concentrations were significantly decreased by the vegan diet. The levels of serum cholestanol and lathosterol also decreased, but serum cholestanol:total cholesterol and lathosterol:total cholesterol did not change. The effect of a vegan diet on serum plant sterols was divergent as the concentration of campesterol decreased while that of sitosterol increased. This effect resulted in a significantly greater sitosterol:campesterol value in the vegan diet group than in the control group (1.48 (SD 0.39) v. 0.72 (SD 0.14); P < 0.001). A higher concentration of campesterol compared with sitosterol is normal in omnivorous subjects and can be explained by lower absorption and esterification rates of sitosterol. Our results suggest that a strict uncooked vegan diet changes the relative absorption rates of these sterols and/or their biliary clearance.
在类风湿性关节炎患者中研究了严格的生食纯素饮食对血清脂质和甾醇浓度的影响。受试者被随机分为纯素饮食组（n = 16），该组食用纯素饮食2 - 3个月，或分为对照组（n = 13），该组继续其通常的杂食饮食。纯素饮食使血清总胆固醇、低密度脂蛋白胆固醇和磷脂浓度显著降低。血清胆甾烷醇和羊毛甾醇水平也降低，但血清胆甾烷醇：总胆固醇和羊毛甾醇：总胆固醇未发生变化。纯素饮食对血清植物甾醇的影响存在差异，因为菜油甾醇浓度降低而甾醇浓度升高。这种影响导致纯素饮食组的甾醇：菜油甾醇值显著高于对照组（1.48（标准差0.39）对0.72（标准差0.14）；P < 0.001）。在杂食受试者中，菜油甾醇浓度高于甾醇是正常的，这可以通过甾醇较低的吸收率和酯化率来解释。我们的结果表明，严格的生食纯素饮食改变了这些甾醇的相对吸收率和/或它们的胆汁清除率。
