Janovská D, Hulínská D, Godová T
Centre of Preventive Medicine, Department of Epidemiology, 3rd Medical Faculty, Charles University, Prague, Czech Republic.
Cent Eur J Public Health. 2001 Feb;9(1):38-40.
We tested in vitro susceptibility of 5 strains of Borrelia burgdorferi sensu lato, isolated from patients in the Czech Republic, to penicillin G, ceftriaxone, cefotaxime, doxycycline and amoxycillin combined with clavulanic acid by broth macrodilution method on BSK medium. Results confirmed high efficacy of the tested drugs, particularly on B. afzelii and B. burgdorferi sensu stricto. A strain of B. garinii, isolated from cerebrospinal fluid, required a longer period of antibiotic activity before inhibitory effects were achieved. Penicillin G was effective only in higher concentrations, attainable by i. v. application. Ceftriaxone had the strongest borreliacidal activity.
我们采用肉汤稀释法，在BSK培养基上测试了从捷克共和国患者体内分离出的5株伯氏疏螺旋体狭义种对青霉素G、头孢曲松、头孢噻肟、多西环素以及阿莫西林与克拉维酸合剂的体外敏感性。结果证实了所测试药物的高效性，尤其是对阿氏疏螺旋体和狭义伯氏疏螺旋体。从脑脊液中分离出的一株伽氏疏螺旋体，在达到抑制效果之前需要更长时间的抗生素作用。青霉素G仅在静脉注射可达到的较高浓度下才有效。头孢曲松具有最强的杀疏螺旋体活性。
