Hook-Nikanne J, Varjonen E, Harvima R J, Kosunen T U
Department of Dermatology, Helsinki University, Central Hospital, Finland.
Acta Derm Venereol. 2000 Nov-Dec;80(6):425-6. doi: 10.1080/000155500300012837.
There have been controversial reports of an elevated prevalence rate of Helicobacter pylori infection in chronic urticaria patients. Furthermore, in some studies remission of chronic urticaria has been reported after eradication of H. pylori. The aim of this investigation was to evaluate the prevalence of H. pylori infection among chronic urticaria patients and to study the effect of eradication therapy on urticaria symptoms. Chronic urticaria patients (n=235) were enrolled and H. pylori status was determined serologically. Thirty-five patients received antimicrobial triple therapy. 25% of the patients were positive for H. pylori. The prevalence of H. pylori infection was not significantly higher among urticaria patients compared with the normal Finnish population in any of the age groups studied. Of the successfully treated patients, 27% showed remission of urticaria. Our data suggest that the prevalence of H. pylori infection is not elevated among chronic urticaria patients and that H. pylori eradication does not appear to influence the course of chronic urticaria.
关于慢性荨麻疹患者幽门螺杆菌感染患病率升高的报道存在争议。此外，在一些研究中，有报道称根除幽门螺杆菌后慢性荨麻疹得到缓解。本研究的目的是评估慢性荨麻疹患者中幽门螺杆菌感染的患病率，并研究根除治疗对荨麻疹症状的影响。纳入了235例慢性荨麻疹患者，并通过血清学方法确定幽门螺杆菌感染状况。35例患者接受了抗菌三联疗法。25%的患者幽门螺杆菌呈阳性。在任何研究的年龄组中，荨麻疹患者中幽门螺杆菌感染的患病率与正常芬兰人群相比均无显著升高。在成功治疗的患者中，27%的患者荨麻疹症状得到缓解。我们的数据表明，慢性荨麻疹患者中幽门螺杆菌感染的患病率并未升高，而且根除幽门螺杆菌似乎不会影响慢性荨麻疹的病程。
