Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, DK-5000 Odense C, Denmark.
Contact Dermatitis. 2012 May;66(5):241-6. doi: 10.1111/j.1600-0536.2011.02052.x.
The development of mixes containing Compositae plant extracts has improved the diagnosis of Compositae contact allergy, but none of them has fulfilled the criteria for an ideal European plant mix.
To evaluate which constituents of two commercial Compositae mixes were most useful as screening agents.
These comprised 76 patients testing positive to Compositae mix 6% in petrolatum and 29 patients testing positive to Compositae mix 5% pet., all of whom were tested with constituents of the respective mixes.
The majority of patients tested positive to parthenolide or parthenolide-containing extracts, followed by German chamomile, yarrow, and arnica. As German chamomile is a weak sensitizer, the results suggest cross-reactions or reactions to unknown allergens. No one was positive to Roman chamomile.
Even though parthenolide seems to be a suitable supplement to the baseline series, the results emphasize that it is important to patch test with extracts of native or locally grown plants, not only because of the geographical variation, but also because of the potential unknown allergens contained in short ether preparations and the variability in the individual patient's exposure and cross-reaction patterns.
含菊科植物提取物的混合物的开发提高了对菊科接触过敏的诊断能力，但没有一种混合物符合理想的欧洲植物混合物标准。
评估两种商业菊科混合物中的哪些成分作为筛选剂最有用。
这些患者包括 76 名对 6%菊科混合物 6%石油膏阳性的患者和 29 名对 5%菊科混合物 pet.阳性的患者，所有这些患者均接受了各自混合物成分的测试。
大多数患者对半日花内酯或含半日花内酯的提取物呈阳性反应，其次是德国洋甘菊、蓍草和山金车。由于德国洋甘菊是一种弱致敏原，这些结果表明存在交叉反应或对未知过敏原的反应。没有人对罗马洋甘菊呈阳性。
尽管半日花内酯似乎是基础系列的合适补充，但结果强调了用本地或当地生长的植物的提取物进行斑贴试验很重要，这不仅是因为地理变异，还因为短醚制剂中可能含有未知的过敏原，以及个体患者暴露和交叉反应模式的可变性。
