van Aggel-Leijssen D P, Saris W H, Homan M, van Baak M A
Nutrition, Toxicology and Environmental Research Institute (NUTRIM), Department of Human Biology, Maastricht University, Maastricht, The Netherlands.
Int J Obes Relat Metab Disord. 2001 Jan;25(1):16-23. doi: 10.1038/sj.ijo.0801470.
To investigate the in vivo effect of exercise training at high and low intensity on beta-adrenergic stimulated fat metabolism in obese men at rest.
Twenty-three obese, healthy subjects were randomly divided in a low-intensity exercise training program (40% VO(2max), n=7), a high-intensity exercise training program (70% VO(2max); n=8), or a non-exercising control group (n=8). The exercise training program lasted for 12 weeks with a training frequency of 3 times per week. Before and after the intervention body composition and maximal aerobic capacity were measured as well as fat metabolism at rest and during beta-adrenergic stimulation by isoprenaline. For comparison, six lean subjects served as a control group. They participated in a low-intensity exercise training program and underwent the same measurements as the obese subjects.
Relative fat oxidation decreased significantly during infusion of an increasing dose of isoprenaline in the obese low-intensity and high-intensity exercise training groups as well as in the lean group (P<0.01). Exercise training failed to influence the effect of beta-adrenergic stimulation on relative fat oxidation in obese men at both intensities and in lean men. In addition, beta-adrenergic-mediated lipolysis did not seem to be different after low intensity exercise training in lean and obese men. Lipolysis might be increased after high-intensity exercise training in obese men.
Low- and high-intensity exercise training in obese men failed to affect beta-adrenergic mediated relative fat oxidation in vivo. beta-Adrenergic-mediated lipolysis might be increased in obese men after HI exercise training only. The effect of low-intensity exercise training on beta-adrenergic-mediated fat metabolism was similar in lean and obese men. International Journal of Obesity (2001) 25, 16-23
研究高低强度运动训练对肥胖男性静息状态下β-肾上腺素能刺激脂肪代谢的体内影响。
23名肥胖健康受试者被随机分为低强度运动训练组（40%最大摄氧量，n = 7）、高强度运动训练组（70%最大摄氧量；n = 8）或非运动对照组（n = 8）。运动训练计划持续12周，每周训练3次。干预前后测量身体成分和最大有氧能力，以及静息状态下和异丙肾上腺素β-肾上腺素能刺激期间的脂肪代谢。作为对照，选取6名瘦人作为对照组。他们参加低强度运动训练计划并接受与肥胖受试者相同的测量。
在肥胖低强度和高强度运动训练组以及瘦人组中，随着异丙肾上腺素剂量增加，相对脂肪氧化显著降低（P<0.01）。运动训练未能影响两种强度的肥胖男性和瘦人男性中β-肾上腺素能刺激对相对脂肪氧化的作用。此外，低强度运动训练后，瘦人和肥胖男性的β-肾上腺素能介导的脂肪分解似乎没有差异。肥胖男性高强度运动训练后脂肪分解可能增加。
肥胖男性的低强度和高强度运动训练未能影响体内β-肾上腺素能介导的相对脂肪氧化。仅在肥胖男性高强度运动训练后，β-肾上腺素能介导的脂肪分解可能增加。低强度运动训练对β-肾上腺素能介导的脂肪代谢的影响在瘦人和肥胖男性中相似。《国际肥胖杂志》（2001年）25卷，16 -
