Crosson B, Sadek J R, Maron L, Gökçay D, Mohr C M, Auerbach E J, Freeman A J, Leonard C M, Briggs R W
University of Florida, USA.
J Cogn Neurosci. 2001 Feb 15;13(2):272-83. doi: 10.1162/089892901564225.
Goldberg (1985) hypothesized that as language output changes from internally to externally guided production, activity shifts from supplementary motor area (SMA) to lateral premotor areas, including Broca's area. To test this hypothesis, 15 right-handed native English speakers performed three word generation tasks varying in the amount of internal guidance and a repetition task during functional magnetic resonance imaging (fMRI). Volumes of significant activity for each task versus a resting state were derived using voxel-by-voxel repeated-measures t tests (p <.001) across subjects. Changes in the size of activity volumes for left medial frontal regions (SMA and pre-SMA/BA 32) versus left lateral frontal regions (Broca's area, inferior frontal sulcus) were assessed as internal guidance of word generation decreased and external guidance increased. Comparing SMA to Broca's area, Goldberg's hypothesis was not verified. However, pre-SMA/BA 32 activity volumes decreased significantly and inferior frontal sulcus activity volumes increased significantly as word generation tasks moved from internally to externally guided.
戈德堡（1985年）提出假设，随着语言输出从内部引导的产生转变为外部引导的产生，活动从辅助运动区（SMA）转移到外侧运动前区，包括布洛卡区。为了验证这一假设，15名以英语为母语的右利手受试者在功能磁共振成像（fMRI）期间执行了三项在内部引导量上有所不同的单词生成任务以及一项重复任务。通过对受试者进行逐体素重复测量t检验（p <.001），得出每项任务相对于静息状态的显著活动体积。随着单词生成的内部引导减少而外部引导增加，评估了左内侧额叶区域（SMA和前SMA/BA 32）与左外侧额叶区域（布洛卡区、额下沟）活动体积大小的变化。将SMA与布洛卡区进行比较，戈德堡的假设未得到验证。然而，随着单词生成任务从内部引导转变为外部引导，前SMA/BA 32的活动体积显著减小，额下沟的活动体积显著增加。
