Allouch P, Pina P, Chaplain C, Delarbre J M, Geffroy F, Grasmick C P, Marcolin M, Morel A, Pangon B, Rio Y, Sédaillan A
Service d'hygiène hospitalière, hôpital A.-Mignot, 177, route de Versailles, 78150 Le Chesnay, France.
Pathol Biol (Paris). 2000 Oct;48(8):792-5.
The glycopeptide susceptibility of 443 clinical isolates of gram-positive cocci collected from nine general hospitals in 1996 was determined according to the recommendations of the CA-SFM (the Antibiogram Committee of the French Society for Microbiology). In total, 234 isolates of Staphylococcus aureus, 84 isolates of coagulase-negative staphylococci (CNS), 98 enterococci and 27 streptococci were collected. The mecA gene confirming resistance to methicillin was found in 42.7% of S. aureus isolates and 51.2% of CNS isolates. No resistance to teicoplanin and vancomycin was found in S. aureus but four isolates of CNS had an MIC of teicoplanin > or = 8 mg/L. All isolates of Enterococcus faecalis tested were susceptible to both glycopeptides. This study confirms that teicoplanin has a very good in vitro activity against gram-positive cocci, isolated in France from nosocomial infections.
按照法国微生物学会抗菌谱委员会（CA-SFM）的建议，对1996年从9家综合医院收集的443株革兰氏阳性球菌临床分离株进行了糖肽敏感性测定。总共收集了234株金黄色葡萄球菌、84株凝固酶阴性葡萄球菌（CNS）、98株肠球菌和27株链球菌。在42.7%的金黄色葡萄球菌分离株和51.2%的CNS分离株中发现了证实对甲氧西林耐药的mecA基因。金黄色葡萄球菌中未发现对替考拉宁和万古霉素耐药，但有4株CNS分离株的替考拉宁MIC≥8mg/L。所有测试的粪肠球菌分离株对这两种糖肽均敏感。本研究证实，替考拉宁对法国医院感染中分离出的革兰氏阳性球菌具有非常好的体外活性。
