Maes M, Ombelet W, De Jongh R, Kenis G, Bosmans E
Department of Psychiatry and Neuropsychology, University Hospital of Maastricht, 6202 AZ Maastricht, The Netherlands.
J Affect Disord. 2001 Mar;63(1-3):85-92. doi: 10.1016/s0165-0327(00)00156-7.
There is now evidence that some patients with major depression show an activation of the inflammatory response system (IRS). This study was carried out to examine whether major depression may induce sensitization with increased IRS responses to the stress of child birth.
Serum concentrations of interleukin-6 (IL-6), the soluble IL-6 receptor (sIL-6R), sgp130 (the IL-6 signal transducing protein) and the sIL-1R antagonist (sIL-1RA) were determined in 16 and 50 women with and without a lifetime history of major depression, respectively. Blood was collected 3-6 days before delivery and 1 and 3 days after delivery. On each occasion the women completed the Zung Depression Rating Scale (ZDS).
Serum IL-6, sIL-6R, sIL-1RA were significantly higher 1 and 3 days after delivery than before. Women who had suffered from a lifetime history of major depression had greater increases in serum IL-6 and sIL-1RA in the early puerperium than women without a lifetime history. Women who had suffered from a lifetime history of major depression had significantly higher IL-6, and sIL-1RA concentrations 1 and 3 days after delivery than women with a negative life-time history.
The responses of IL-6 and sIL-1RA following delivery are amplified in women who previously suffered from major depression. The results suggest that major depression is accompanied by a sensitization of the IRS.
目前有证据表明，一些重度抑郁症患者表现出炎症反应系统（IRS）的激活。本研究旨在探讨重度抑郁症是否会导致机体致敏，使IRS对分娩应激的反应增强。
分别测定了16名有重度抑郁症病史和50名无重度抑郁症病史的女性血清中白细胞介素-6（IL-6）、可溶性IL-6受体（sIL-6R）、sgp130（IL-6信号转导蛋白）和sIL-1受体拮抗剂（sIL-1RA）的浓度。在分娩前3 - 6天、分娩后1天和3天采集血液。每次采血时，这些女性都要完成zung抑郁自评量表（ZDS）。
分娩后1天和3天血清IL-6、sIL-6R、sIL-1RA显著高于分娩前。有重度抑郁症病史的女性在产褥早期血清IL-6和sIL-1RA的升高幅度大于无该病史的女性。有重度抑郁症病史的女性在分娩后1天和3天血清IL-6和sIL-1RA浓度显著高于无该病史的女性。
既往患重度抑郁症的女性在分娩后IL-6和sIL-1RA的反应增强。结果表明，重度抑郁症伴有IRS致敏。
