Zywicka-Lopaciuk H, Zdziechowska H, Krzyzanowska J, Woźniewska M, Sobczyńska Z, Sielczak M
Acta Haematol Pol. 1975 Jan-Mar;6(1):11-26.
Investigations were carried out on 261 patients with chronic lymphatic leukaemia with survival over 4 years. The following problems were discussed: age and sex of patients, presenting symptoms, organ changes, laboratory investigations, infectious complications, coexistence of malignant tumours. Correlations were established between various parameters and the length of survival. It was demonstrated that patients without palpable lymph nodes and spleen at the beginning of the diseases and with leucocyte counts ranging from 10,000 to 100,000/1 mm-3 have a better prognosis, while thrombocytopenia even without haemorrhagic diathesis is a poor prognostic sign. Infections were observed in 50 percent of cases, more frequently in patients with hypogammaglobulinaemia. Coexistence of malignant tumours was found in 5.4 percent of cases. Pathological examinations including organ biopsy and autopsy failed to demonstrate characteristic features of lymphatic system proliferation as compared with patients with short survival.
对261例存活超过4年的慢性淋巴细胞白血病患者进行了调查。讨论了以下问题：患者的年龄和性别、首发症状、器官变化、实验室检查、感染并发症、恶性肿瘤的共存情况。建立了各种参数与生存时长之间的相关性。结果表明，疾病初发时无可触及淋巴结和脾脏且白细胞计数在10,000至100,000/1 mm³之间的患者预后较好，而即使没有出血素质的血小板减少也是预后不良的迹象。50%的病例观察到感染，在低丙种球蛋白血症患者中更常见。5.4%的病例发现有恶性肿瘤共存。与存活期短的患者相比，包括器官活检和尸检在内的病理检查未能显示淋巴系统增殖的特征性表现。
