Calcineurin inhibition and cardiac hypertrophy: a matter of balance.
作者信息
Leinwand L A
机构信息
Department of Molecular, Cellular, and Developmental Biology, Porter Addition, Room A3B40, University of Colorado, Boulder, CO 80309-0347, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):2947-9. doi: 10.1073/pnas.051033698.
Abstract
摘要
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本文引用的文献
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Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo.富含肌细胞的钙调神经磷酸酶相互作用蛋白（MCIP1）在体内可抑制心肌肥大。
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3328-33. doi: 10.1073/pnas.041614798.
2
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo.钙调神经磷酸酶的靶向抑制可减轻体内心肌肥大。
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3322-7. doi: 10.1073/pnas.031371998.
3
Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles.独立信号控制横纹肌中钙调神经磷酸酶抑制蛋白MCIP1和MCIP2的表达。
Circ Res. 2000 Dec 8;87(12):E61-8. doi: 10.1161/01.res.87.12.e61.
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Calcineurin blockade prevents cardiac mitogen-activated protein kinase activation and hypertrophy in renovascular hypertension.钙调神经磷酸酶阻断可预防肾血管性高血压中心脏丝裂原活化蛋白激酶的激活及心肌肥大。
J Biol Chem. 2000 Dec 29;275(52):40867-73. doi: 10.1074/jbc.M008071200.
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A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.唐氏综合征关键区域内编码的一种蛋白质在横纹肌中富集，并抑制钙调神经磷酸酶信号传导。
J Biol Chem. 2000 Mar 24;275(12):8719-25. doi: 10.1074/jbc.275.12.8719.
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Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy.钙调神经磷酸酶的靶向抑制可预防激动剂诱导的心肌细胞肥大。
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7
Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy.钙调神经磷酸酶在压力超负荷诱导的心肌肥大中起关键作用。
Circulation. 1999 Dec 14;100(24):2449-54. doi: 10.1161/01.cir.100.24.2449.
8
Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure.环孢素可减轻小鼠压力超负荷引起的心肌肥厚，同时增加失代偿和心力衰竭的易感性。
Circ Res. 1999 Apr 2;84(6):735-40. doi: 10.1161/01.res.84.6.735.
9
Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin.压力过载会在接受环孢素（一种钙调神经磷酸酶抑制剂）治疗的小鼠中诱发严重的肥大。
Circ Res. 1999 Apr 2;84(6):729-34. doi: 10.1161/01.res.84.6.729.
10
Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats.钙调神经磷酸酶抑制剂未能预防大鼠压力超负荷引起的左心室肥厚。
Circ Res. 1999 Apr 2;84(6):722-8. doi: 10.1161/01.res.84.6.722.
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