大剂量盐酸氯丙嗪治疗后的角膜沉着
Corneal deposition after high-dose chlorpromazine hydrochloride therapy.
作者信息
Webber S K, Domniz Y, Sutton G L, Rogers C M, Lawless M A
机构信息
Sydney Refractive Surgery Centre, Chatswood, NSW, Australia.
出版信息
Cornea. 2001 Mar;20(2):217-9. doi: 10.1097/00003226-200103000-00023.
PURPOSE
To report a case of dermal and ocular changes after prolonged use of high-dose chlorpromazine hydrochloride therapy.
METHOD
This case report includes clinical history, clinical findings, and photographic images of ocular and dermal changes. RESULTS. Chlorpromazine therapy in a cumulative dosage exceeding 1,100 g resulted in dramatic skin discoloration and multiple crystalline deposits in both corneas. Anterior capsular opacities were binocularly present. These changes were sufficient to cause reduction in visual acuity.
CONCLUSIONS
Chlorpromazine deposition at high levels can cause reduction in visual acuity and significant skin discoloration.
目的
报告一例长期使用大剂量盐酸氯丙嗪治疗后出现皮肤和眼部改变的病例。
方法
本病例报告包括临床病史、临床检查结果以及眼部和皮肤改变的照片。
结果
累积剂量超过1100克的氯丙嗪治疗导致皮肤显著变色以及双眼角膜出现多个结晶沉积物。双眼均出现前囊膜混浊。这些改变足以导致视力下降。
结论
高水平的氯丙嗪沉积可导致视力下降和明显的皮肤变色。
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