Phua Yun Shan, Patel Dipika V, McGhee Charles N J
Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019 Auckland, New Zealand.
Graefes Arch Clin Exp Ophthalmol. 2005 Jul;243(7):721-3. doi: 10.1007/s00417-004-0982-z. Epub 2005 Mar 3.
Deposits in the cornea and lens are a known complication of long-term chlorpromazine therapy.
A 59-year-old woman had previously taken chlorpromazine for 20 years with doses up to 1,200 mg/day, with a mean dose of 400 mg/day. She presented with gradual onset of blurred vision in her left eye. Slit-lamp biomicroscopy revealed multiple fine creamy-white deposits on her corneal endothelium and anterior crystalline lens capsule bilaterally.
In vivo confocal microscopy of the cornea identified irregular hyper-reflective deposits on the posterior surface of the endothelium. The deposits varied from 1 microm to 70 microm in diameter and had well-defined edges. Endothelial morphology was otherwise normal bilaterally.
This is the first report of in vivo confocal imaging of deposits resulting from long-term chlorpromazine use. Microstructural analysis of the corneal endothelium reveals that there were no abnormalities in cellular morphology resulting from these deposits.
角膜和晶状体沉积是长期使用氯丙嗪治疗已知的并发症。
一名59岁女性此前服用氯丙嗪20年，剂量高达每日1200毫克，平均剂量为每日400毫克。她出现左眼视力逐渐模糊。裂隙灯生物显微镜检查发现双侧角膜内皮和晶状体前囊有多处细小的乳脂样白色沉积物。
角膜活体共聚焦显微镜检查发现内皮后表面有不规则的高反射沉积物。沉积物直径从1微米到70微米不等，边缘清晰。双侧内皮形态其他方面正常。
这是关于长期使用氯丙嗪所致沉积物的活体共聚焦成像的首次报告。角膜内皮的微观结构分析显示，这些沉积物未导致细胞形态异常。
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