Amir R, Dunham M E
Department of Otolaryngology -- Head and Neck Surgery, University of Illinois Eye and Ear Infirmary, Building 902, 1855 West Taylor St., Chicago, IL 60612, USA.
Int J Pediatr Otorhinolaryngol. 2001 Apr 6;58(1):81-5. doi: 10.1016/s0165-5876(00)00463-8.
The relationship of choanal atresia to various systemic malformations is well acknowledged by the CHARGE acronym: colobomas, heart defects, atresia choanae, retarded growth and development, genito-urinary defects, and ear defects. In the past, we have reported the finding of an isolated skull base malformation associated with choanal atresia. We report here a unique case of choanal atresia associated with a patent foramen cecum and intracranial extension of a dermoid sinus. The embryogenesis of this condition is accounted for by the mesodermal flow theory of choanal atresia formation, and implies a need for thorough imaging of the anterior skull base in cases of bilateral atresia.
后鼻孔闭锁与各种全身畸形的关系通过CHARGE首字母缩写被广泛认可：眼裂、心脏缺陷、后鼻孔闭锁、生长发育迟缓、泌尿生殖系统缺陷和耳部缺陷。过去，我们曾报告过与后鼻孔闭锁相关的孤立性颅底畸形的发现。我们在此报告一例独特的后鼻孔闭锁病例，该病例伴有盲孔开放和皮样窦道的颅内延伸。这种情况的胚胎发生可由后鼻孔闭锁形成的中胚层流动理论来解释，这意味着在双侧闭锁的病例中需要对前颅底进行全面成像。
