Leclerc J E, Fearon B
Department of Otolaryngology, Centre Hospitalier de l'Université Laval, Quebec City, Canada.
Int J Pediatr Otorhinolaryngol. 1987 Oct;13(3):265-72. doi: 10.1016/0165-5876(87)90107-8.
The authors have studied 130 cases of choanal malformation. They found 53 bilateral atresias, 51 unilateral atresias and 26 cases of choanal stenosis. Fifty-seven of these cases were associated with other anomalies and 38 had at least two features of the CHARGE association (C, colobomas; H, heart defects; A, atresia choanae; R, retarded growth; G, genito-urinary defects; E, ear defects). The pathogenesis of choanal atresia in regard to the abnormal migration of neuroectodermal cells is discussed.
作者研究了130例后鼻孔畸形病例。他们发现53例双侧闭锁、51例单侧闭锁和26例后鼻孔狭窄。其中57例伴有其他异常，38例至少具有CHARGE综合征（C，脉络膜缺损；H，心脏缺陷；A，后鼻孔闭锁；R，生长发育迟缓；G，泌尿生殖系统缺陷；E，耳部缺陷）的两种特征。本文讨论了神经外胚层细胞异常迁移导致后鼻孔闭锁的发病机制。
