Duncan N O, Miller R H, Catlin F I
Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, TX 77030.
Int J Pediatr Otorhinolaryngol. 1988 May;15(2):129-35. doi: 10.1016/0165-5876(88)90063-8.
Over the past few years there has been increasing awareness of the association of choanal atresia with other congenital defects. Thirty-one cases of choanal atresia were reviewed and other congenital anomalies were documented in 19 patients. These other anomalies were identified in 75% of the 20 patients with bilateral choanal atresia but in only 36% of the 11 patients with unilateral choanal atresia. Associated defects largely occurred in a predictable pattern described by the CHARGE mnemonic: C-coloboma, H-heart disease, A-atresia choanae, R-retarded growth, G-genital hypoplasia, E-ear defects. The implications of the CHARGE association in the management of patients with choanal atresia are discussed.
在过去几年中，人们越来越意识到后鼻孔闭锁与其他先天性缺陷之间的关联。回顾了31例后鼻孔闭锁病例，记录到19例存在其他先天性异常。在20例双侧后鼻孔闭锁患者中，75%发现了这些其他异常，而在11例单侧后鼻孔闭锁患者中，只有36%发现了这些异常。相关缺陷大多以CHARGE记忆法描述的可预测模式出现：C-缺损，H-心脏病，A-后鼻孔闭锁，R-生长发育迟缓，G-生殖器发育不全，E-耳部缺陷。本文讨论了CHARGE关联在后鼻孔闭锁患者管理中的意义。
