以果蝇作为模式昆虫。

Using Drosophila as a model insect.

作者信息

Schneider D

机构信息

Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

出版信息

Nat Rev Genet. 2000 Dec;1(3):218-26. doi: 10.1038/35042080.

DOI:10.1038/35042080

PMID:11252751

Abstract

The fruit fly Drosophila melanogaster has become such a popular model organism for studying human disease that it is often described as a little person with wings. This view has been strengthened with the sequencing of the Drosophila genome and the discovery that 60% of human disease genes have homologues in the fruit fly. In this review, I discuss the approach of using Drosophila not only as a model for metazoans in general but as a model insect in particular. Specifically, I discuss recent work on the use of Drosophila to study the transmission of disease by insect vectors and to investigate insecticide function and development.

摘要

果蝇已成为研究人类疾病的一种非常受欢迎的模式生物，以至于它常被描述为长着翅膀的小人类。随着果蝇基因组测序以及发现60%的人类疾病基因在果蝇中有同源物，这种观点得到了强化。在这篇综述中，我不仅讨论了将果蝇用作后生动物一般模型的方法，还特别讨论了将其用作昆虫模型的方法。具体而言，我讨论了最近利用果蝇研究昆虫媒介传播疾病以及研究杀虫剂功能和发育的工作。