细胞内晶体形成作为小鼠肺新型隐球菌感染中细胞毒性的一种机制。
Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection.
作者信息
Feldmesser M, Kress Y, Casadevall A
机构信息
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
出版信息
Infect Immun. 2001 Apr;69(4):2723-7. doi: 10.1128/IAI.69.4.2723-2727.2001.
Abstract
Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.
摘要
在C57BL/6小鼠嗜酸性新型隐球菌肺炎期间形成的棒状晶体结构。发现晶体与酵母细胞相关，并游离于宿主细胞质中。这些晶体显然是由于宿主蛋白与隐球菌多糖相互作用而形成的。晶体形成可能通过造成细胞损伤而促进发病机制。
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