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本文引用的文献

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Nonencapsulated Variant of Cryptococcus neoformans I. Virulence Studies and Characterization of Soluble Polysaccharide.新型隐球菌非包被变异株 I. 毒力研究及可溶性多糖的特性。
Infect Immun. 1971 Feb;3(2):287-94. doi: 10.1128/iai.3.2.287-294.1971.
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Pulmonary adenomatosis in mice.小鼠肺腺瘤病
J Natl Cancer Inst. 1952 Jun;12(6):1297-1315.
3
Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection.新型隐球菌是小鼠肺部感染中的兼性细胞内病原体。
Infect Immun. 2000 Jul;68(7):4225-37. doi: 10.1128/IAI.68.7.4225-4237.2000.
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Synthesis of polymerized melanin by Cryptococcus neoformans in infected rodents.新型隐球菌在受感染啮齿动物体内合成聚合黑色素。
Infect Immun. 2000 May;68(5):2845-53. doi: 10.1128/IAI.68.5.2845-2853.2000.
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Biochemical characterization of endogenously formed eosinophilic crystals in the lungs of mice.小鼠肺内内源性形成的嗜酸性晶体的生化特性
J Biol Chem. 2000 Mar 17;275(11):8032-7. doi: 10.1074/jbc.275.11.8032.
6
Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies.一种针对新型隐球菌多糖的鼠单克隆抗体的特性分析，该抗体是人类治疗研究的候选药物。
Antimicrob Agents Chemother. 1998 Jun;42(6):1437-46. doi: 10.1128/AAC.42.6.1437.
7
Effect of antibody to capsular polysaccharide on eosinophilic pneumonia in murine infection with Cryptococcus neoformans.抗荚膜多糖抗体对新生隐球菌小鼠感染中嗜酸性肺炎的影响。
J Infect Dis. 1998 Jun;177(6):1639-46. doi: 10.1086/515314.
8
IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL/6).在基因易感小鼠（C57BL/6）肺部新型隐球菌感染期间，嗜酸性粒细胞募集、晶体沉积和单核细胞募集需要白细胞介素-5。
J Immunol. 1998 Mar 1;160(5):2393-400.
9
What makes Cryptococcus neoformans a pathogen?是什么让新型隐球菌成为一种病原体？
Emerg Infect Dis. 1998 Jan-Mar;4(1):71-83. doi: 10.3201/eid0401.980109.
10
Microevolution of a standard strain of Cryptococcus neoformans resulting in differences in virulence and other phenotypes.新型隐球菌标准菌株的微进化导致毒力和其他表型的差异。
Infect Immun. 1998 Jan;66(1):89-97. doi: 10.1128/IAI.66.1.89-97.1998.

细胞内晶体形成作为小鼠肺新型隐球菌感染中细胞毒性的一种机制。

Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection.

作者信息

Feldmesser M, Kress Y, Casadevall A

机构信息

Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

出版信息

Infect Immun. 2001 Apr;69(4):2723-7. doi: 10.1128/IAI.69.4.2723-2727.2001.

DOI:10.1128/IAI.69.4.2723-2727.2001
PMID:11254641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC98213/
Abstract

Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.

摘要

在C57BL/6小鼠嗜酸性新型隐球菌肺炎期间形成的棒状晶体结构。发现晶体与酵母细胞相关，并游离于宿主细胞质中。这些晶体显然是由于宿主蛋白与隐球菌多糖相互作用而形成的。晶体形成可能通过造成细胞损伤而促进发病机制。