Dowsett E G, Herson R N, Maxted W R, Widdowson J P
Br Med J. 1975 Mar 1;1(5956):500-2. doi: 10.1136/bmj.1.5956.500.
In an outbreak of idiopathic erysipelas ten women patients, aged 42-74, in a long-stay unit of a psychiatric hospital were simultaneously affected. Group A streptococci M-type 1 were isolated from two isolated from two patients with erysipelas and 18 carriers, but subsequent serological tests for type-specific antibody, antistreptolysin O, and anti-deoxyribonuclease B showed that the infection had been widespread in the unit. Treatment with ampicillin proved ineffective and to prevent relapse it was substituted by a standard course of intramuscular penicillin. This seems to be the first epidemic of this type to be reported and certainly the first outbreak of idiopathic erysipelas to be investigated by modern serological techniques.
在一家精神病院长住病房发生的特发性丹毒疫情中,10名年龄在42至74岁的女性患者同时受到感染。从两名丹毒患者和18名携带者中分离出了A组1型链球菌,但随后针对特异性抗体、抗链球菌溶血素O和抗脱氧核糖核酸酶B的血清学检测表明,该病房内感染已广泛传播。事实证明,氨苄青霉素治疗无效,为防止复发,改用标准疗程的肌肉注射青霉素。这似乎是首次报告的此类疫情,肯定也是首次运用现代血清学技术调查的特发性丹毒疫情。