Lakho G R, Nazir K, Chundrigar T, Jabeen N, Qureshi M A
Department of Physiology, Jinnah Medical College, Karachi.
J Pak Med Assoc. 2001 Jan;51(1):32-6.
To determine the serum leptin levels in Pakistani pregnant subjects at the time of delivery and to ascertain the relationship between serum leptin levels and related variables (weight, body mass index, placental weight, gestational age, parity) at delivery.
Lady Dufferin Hospital, and Ziauddin Hospital Karachi.
Leptin concentration was measured in 110 subjects from venous samples, using Active Human ELISA Kit (DSL-10-23100). Samples were selected according to the availability.
Mean maternal weight, body mass index and placental weight were 64.3 +/- 13.8 kg, 27.1 +/- 5.8 kg/m2 and 523.5 +/- 90 gm, respectively. Gestational age was 36-41 weeks and maternal age was 18-35 years. Mean serum leptin level was 27.9 +/- 18.1 ng/ml. Serum leptin levels were found to be positively correlated with body weight (r = 0.73, p < 0.01), body mass index (r = 0.80, p < 0.01) and placental weight (r = 0.34, p < 0.05). Increased leptin levels were found in multigravida mothers (mean 30.2 +/- 17.5) than in primigravida mothers (23.1 +/- 18.9).
Our results suggest that leptin does play role in body weight and energy regulation during pregnancy. The significant positive correlation between leptin and placental weight suggests that placenta may be the site of synthesis and/or secretion of leptin during pregnancy.
测定巴基斯坦孕妇分娩时的血清瘦素水平，并确定分娩时血清瘦素水平与相关变量（体重、体重指数、胎盘重量、孕周、产次）之间的关系。
卡拉奇的杜弗林夫人医院和齐亚乌丁医院。
使用活性人酶联免疫吸附测定试剂盒（DSL - 10 - 23100），从110名受试者的静脉样本中测量瘦素浓度。样本根据可得性进行选择。
母亲的平均体重、体重指数和胎盘重量分别为64.3±13.8千克、27.1±5.8千克/平方米和523.5±90克。孕周为36 - 41周，母亲年龄为18 - 35岁。平均血清瘦素水平为27.9±18.1纳克/毫升。发现血清瘦素水平与体重（r = 0.73，p < 0.01）、体重指数（r = 0.80，p < 0.01）和胎盘重量（r = 0.34，p < 0.05）呈正相关。经产妇母亲（平均30.2±17.5）的瘦素水平高于初产妇母亲（23.1±18.9）。
我们的结果表明，瘦素在孕期体重和能量调节中确实发挥作用。瘦素与胎盘重量之间的显著正相关表明，胎盘可能是孕期瘦素合成和/或分泌的部位。
