Kristensen J K, From E
Br J Vener Dis. 1975 Feb;51(1):31-3. doi: 10.1136/sti.51.1.31.
419 patients with uncomplicated gonorrhoea were treated with sulphamethoxazole 4 g. combined with trimethoprim 0-8 g. divided into two doses with an 8-hr interval. The failure rate was 1-9 per cent. Parallel with this trial, 319 patients received pivampicillin 1-4 g. combined with probenecid 1 g,; the failure rate was 0-9 per cent. Side-effects were few, four patients in the first group and one in the second group developing a rash. No recurrences were noted in nine patients treated for tonsillar gonorrhoea with the trimethoprim-sulphamethoxazole schedule, while two recurrences were found in thirteen patients treated with pivampicillin-probenecid. The frequency of post-gonococcal urethritis was 7-7 per cent. in the pivampicillin-pro-benecid group against 3-4 per cent. in the trimethoprim-sulphamethoxazole group, a difference which was not statistically significant.
419例单纯性淋病患者接受了4克磺胺甲恶唑联合0.8克甲氧苄啶的治疗，分两次给药，间隔8小时。失败率为1.9%。与该试验并行，319例患者接受了1.4克匹氨西林联合1克丙磺舒的治疗；失败率为0.9%。副作用很少，第一组有4例患者，第二组有1例患者出现皮疹。采用甲氧苄啶-磺胺甲恶唑方案治疗扁桃体淋病的9例患者未出现复发，而采用匹氨西林-丙磺舒治疗的13例患者中有2例复发。淋菌性尿道炎的发生率在匹氨西林-丙磺舒组为7.7%，在甲氧苄啶-磺胺甲恶唑组为3.4%，该差异无统计学意义。
