Omata Y, Satake M, Maeda R, Saito A, Shimazaki K, Yamauchi K, Uzuka Y, Tanabe S, Sarashina T, Mikami T
Department of Veterinary Physiology, Obihiro University of Agriculture and Veterinary Medicine, Japan.
J Vet Med Sci. 2001 Feb;63(2):187-90. doi: 10.1292/jvms.63.187.
Sporozoites of Toxoplasma gondii preincubated with lactoferricin showed decreased activity in penetration of mouse embryonal cells. Mice inoculated with 10(5) sporozoites preincubated with lactoferricin showed a higher survival rate than those inoculated with the same number of untreated sporozoites. Likewise, sporozoites of Eimeria stiedai preincubated with lactoferricin also showed decreased activity in penetration of rabbit hepatobiliary cells. Rabbits inoculated with 10(5) sporozoites preincubated with lactoferricin shed fewer oocysts than those inoculated with the same number of untreated sporozoites. These results indicate that lactoferricin is effective to reduce the infectivity of sporozoites of Toxoplasma gondii and Eimeria stiedai.
与乳铁传递蛋白素预孵育的刚地弓形虫子孢子在穿透小鼠胚胎细胞时活性降低。接种了10⁵个与乳铁传递蛋白素预孵育的子孢子的小鼠比接种相同数量未处理子孢子的小鼠存活率更高。同样，与乳铁传递蛋白素预孵育的斯氏艾美耳球虫子孢子在穿透兔肝胆细胞时活性也降低。接种了10⁵个与乳铁传递蛋白素预孵育的子孢子的兔子排出的卵囊比接种相同数量未处理子孢子的兔子少。这些结果表明乳铁传递蛋白素可有效降低刚地弓形虫和斯氏艾美耳球虫子孢子的感染性。
