Bezold G, Lange M, Schiener R, Palmedo G, Sander C A, Kerscher M, Peter R U
Department of Dermatology, University of Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany.
Br J Dermatol. 2001 Mar;144(3):614-8. doi: 10.1046/j.1365-2133.2001.04096.x.
Diagnosis of scabies infection can be difficult as in many cases only few mites are present on an infected person, and in some cases the skin manifestations can be subtle or atypical. We describe the use of polymerase chain reaction (PCR) to amplify Sarcoptes scabiei DNA in a patient presenting with clinically atypical eczema. Cutaneous scales were PCR positive for S. scabiei DNA before, and negative 2 weeks after, therapy. This method facilitates fast and very sensitive diagnosis of clinically atypical or inapparent scabies infection and therapy control in severely affected patients and may help to identify previously unrecognized scabies cases.
疥疮感染的诊断可能很困难，因为在许多情况下，感染者身上仅存在少量螨虫，而且在某些情况下，皮肤表现可能很轻微或不典型。我们描述了在一名患有临床非典型湿疹的患者中使用聚合酶链反应（PCR）扩增疥螨DNA的情况。治疗前，皮肤鳞屑的疥螨DNA PCR检测呈阳性，治疗2周后呈阴性。该方法有助于对临床非典型或隐匿性疥疮感染进行快速且非常敏感的诊断，并对重症患者的治疗进行监测，可能有助于识别之前未被认识到的疥疮病例。
