新月弯孢霉ATCC 12017对雪松醇的生物转化

Biotransformation of cedrol by Curvularia lunata ATCC 12017.

作者信息

Collins D O, Reese P B

机构信息

Department of Chemistry, University of the West Indies, Mona, Kingston, Jamaica.

出版信息

Phytochemistry. 2001 Mar;56(5):417-21. doi: 10.1016/s0031-9422(00)00412-x.

DOI:10.1016/s0031-9422(00)00412-x

PMID:11261573

Abstract

Bioconversion of cedrol (1) with the Curvularia lunata was investigated in two different growth media. Five products were obtained in potato dextrose broth, whereas nine compounds were produced in a medium containing beef extract. Only three of the metabolites: 3beta-hydroxycedrol (2), 3alpha-hydroxycedrol (3) and 12-hydroxycedrol (4) were common to both media. They were also obtained as the major products in each case. Three new derivatives have also been identified.

摘要

研究了在两种不同生长培养基中用新月弯孢霉对雪松醇（1）进行生物转化的情况。在马铃薯葡萄糖肉汤中获得了5种产物，而在含有牛肉提取物的培养基中产生了9种化合物。两种培养基中仅有的3种共同代谢产物为：3β-羟基雪松醇（2）、3α-羟基雪松醇（3）和12-羟基雪松醇（4）。在每种情况下，它们也都是主要产物。还鉴定出了3种新的衍生物。