Koskinen L O, Collin O, Bergh A
Department of Neurosurgery, University Hospital of Umeå, Sweden.
Ups J Med Sci. 2000;105(3):215-26. doi: 10.3109/2000-1967-177.
The acute effects of cigarette smoking and hypoxia on the cerebral and testicular microcirculation were studied in anestethised adult rats. Smoking for 2 min did not influence arterial pO2, pCO2 or pH but it induced an increase in cerebral blood flow by 34% and inhibited vasomotion in the testis for about 1 h. One hour after smoke exposure apnea induced a slight increase in arterial pCO2, a significant decrease in pO2, and an increase in cerebral blood flow (CBF) by 54%. In animals not previously exposed to cigarette smoke apnea increased CBF by 121%, demonstrating that a short-term exposure to tobacco smoke influences the cerebrovascular reactivity for more than one hour. In the testis, apnea resulted in a decreased blood flow by 39% and a complete depression of vasomotion. Breathing 10% O2/90% N2 resulted in moderate hypoxia, a total disappearance of the vasomotion in the testis, a 24% decrease in testicular blood flow, but a 23% increase in CBF.
在麻醉的成年大鼠中研究了吸烟和缺氧对脑和睾丸微循环的急性影响。吸烟2分钟对动脉血氧分压（pO2）、二氧化碳分压（pCO2）或pH值没有影响，但会使脑血流量增加34%，并抑制睾丸血管运动约1小时。吸烟暴露1小时后，呼吸暂停会使动脉pCO2略有升高，pO2显著降低，脑血流量（CBF）增加54%。在未预先接触香烟烟雾的动物中，呼吸暂停会使CBF增加121%，这表明短期接触烟草烟雾会在超过一小时的时间内影响脑血管反应性。在睾丸中，呼吸暂停会使血流量减少39%，并使血管运动完全抑制。吸入10%氧气/90%氮气会导致中度缺氧，睾丸血管运动完全消失，睾丸血流量减少24%，但CBF增加23%。
