Amigo L, Zanlungo S, Mendoza H, Miquel J F, Nervi F
Eur Rev Med Pharmacol Sci. 1999 Nov-Dec;3(6):241-6.
The aim of this article is to present an update of selected aspects of the pathogenesis and risk factors of cholesterol gallstones, a highly prevalent Western disease. The etiology of cholesterol cholelithiasis is considered to be multifactorial, with interaction of genetic and environmental factors. Mechanisms of cholesterol lithogenesis include biliary cholesterol hypersecretion, supersaturation and crystallization, stone formation and growth, and bile stasis within the gallbladder. Each of these various steps could be under genetic control and/or be influenced through intermediate pathogenic steps linked to a variety of environmental factors.
本文旨在介绍胆固醇结石这一西方高发疾病发病机制和危险因素某些方面的最新情况。胆固醇结石病的病因被认为是多因素的，涉及遗传和环境因素的相互作用。胆固醇结石形成的机制包括胆汁中胆固醇分泌过多、过饱和与结晶、结石形成与生长以及胆囊内胆汁淤积。这些不同步骤中的每一步都可能受遗传控制和/或通过与多种环境因素相关的中间致病步骤受到影响。
