Sohn S, Lee E S, Kwon H J, Lee S I, Bang D, Lee S
Laboratory of Cell Biology, Ajou University Institute for Medical Sciences, Suwon, 442-749, Korea.
J Infect Dis. 2001 Apr 15;183(8):1180-6. doi: 10.1086/319681. Epub 2001 Mar 19.
In the etiology of Behçet's disease (BD), viral infection has long been postulated as a contributing factor, and viral involvement has been demonstrated. However, viral infection alone is not sufficient to explain the pathogenesis of BD, and some evidence suggests that immunologic abnormalities are also important. To study the possible role of immune regulation in the development of BD-like symptoms induced by herpes simplex virus inoculation in ICR mice, macrophages were deleted by use of liposome-encapsulated clodronate (lip-Cl(2)MDP). Treatment with lip-Cl(2)MDP suppressed the development of BD-like symptoms, and this suppression was correlated with the induction of interleukin-4 expression in mouse spleens. When the Th2 adjuvant ovalbumin (OVA)-alum was injected into mice with BD-like symptoms, their cutaneous symptoms improved. Adoptive transfer with splenocytes from OVA-alum-injected mice also resulted in improvement. These findings suggest that up-regulated Th2 cytokine expression can attenuate the development of and improve some BD-like symptoms.
在白塞病（BD）的病因学中，长期以来一直假定病毒感染是一个促成因素，并且已经证实病毒参与其中。然而，仅病毒感染不足以解释BD的发病机制，一些证据表明免疫异常也很重要。为了研究免疫调节在单纯疱疹病毒接种诱导的ICR小鼠BD样症状发展中的可能作用，使用脂质体包裹的氯膦酸盐（lip-Cl(2)MDP）清除巨噬细胞。用lip-Cl(2)MDP治疗可抑制BD样症状的发展，这种抑制与小鼠脾脏中白细胞介素-4表达的诱导相关。当将Th2佐剂卵清蛋白（OVA）-明矾注射到有BD样症状的小鼠中时，它们的皮肤症状得到改善。用OVA-明矾注射小鼠的脾细胞进行过继转移也导致症状改善。这些发现表明，上调的Th2细胞因子表达可以减轻BD样症状的发展并改善其中一些症状。
