Sohn S, Lee E S, Bang D, Lee S
Laboratory of Cell Biology, Ajou University Institute for Medical Science, # 442-749, Suwon, Korea.
Eur J Dermatol. 1998 Jan-Feb;8(1):21-3.
Herpes simplex virus (HSV) infection has been suggested to be one of the etiologic or triggering factors in Behçet's disease. To test this hypothesis, 258 ICR mice were inoculated with HSV type 1 (KOS strain). After the induced infection, 86 mice (33.3%) died, 77 (29. 8%) showed Behçet's disease-like symptoms, and 95 (36.8%) had a healthy, normal appearance or just a single symptom. The symptoms included skin ulcers on the earlobe, neck, abdomen, back or face (57. 1%); eye syndromes (39.0%); partial hair loss (33.8%); genital ulcers (19.5%); bullae (11.7%); arthritis (5.2%); gastrointestinal ulcer (5.2%); and tongue ulcers (3.9%). The induced Behçet's disease-like symptoms are similar to the clinical manifestations of ulcers, uveitis, and arthritis which have been significant in diagnosing Behçet's disease in patients.
单纯疱疹病毒（HSV）感染被认为是白塞病的病因或触发因素之一。为验证这一假设，将258只ICR小鼠接种1型单纯疱疹病毒（KOS株）。诱导感染后，86只小鼠（33.3%）死亡，77只（29.8%）出现白塞病样症状，95只（36.8%）外观健康正常或仅有单一症状。症状包括耳垂、颈部、腹部、背部或面部皮肤溃疡（57.1%）；眼部综合征（39.0%）；局部脱发（33.8%）；生殖器溃疡（19.5%）；大疱（11.7%）；关节炎（5.2%）；胃肠道溃疡（5.2%）；以及舌溃疡（3.9%）。诱导产生的白塞病样症状类似于溃疡、葡萄膜炎和关节炎的临床表现，这些表现对诊断白塞病患者具有重要意义。
