Jessell T M
Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Nat Rev Genet. 2000 Oct;1(1):20-9. doi: 10.1038/35049541.
Neural circuits are assembled with remarkable precision during embryonic development, and the selectivity inherent in their formation helps to define the behavioural repertoire of the mature organism. In the vertebrate central nervous system, this developmental program begins with the differentiation of distinct classes of neurons from progenitor cells located at defined positions within the neural tube. The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules.
神经回路在胚胎发育过程中以极高的精度组装而成，其形成过程中固有的选择性有助于界定成熟生物体的行为模式。在脊椎动物的中枢神经系统中，这一发育程序始于位于神经管特定位置的祖细胞分化出不同类型的神经元。在神经系统的许多区域，人们已经研究了确定神经细胞身份的机制，结果显示关键信号分子在细胞命运的确定方面具有高度保守性。
