Li R, Zhuang G, Zhou C
First Affiliated Hospital of Sun Yet-Sen University of Medical Sciences, Guangzhou 510080.
Zhonghua Fu Chan Ke Za Zhi. 1999 Jan;34(1):5-7.
The aim of this study was to examine, retrospectively, the efficacy of intracytoplasmic sperm injection (ICSI) in the treatment of male infertility and idiopathic infertility.
From November 1995 to January 1998, 140 couples (156 cycles) received ICSI because of severe male factor infertility or idiopathic infertility in our assisted reproductive technology center. The treatment cycles were divided into two groups, group I included 74 cycles done before May 1997, group II included 82 cycles done after May 1997. Mature oocytes were selected for microinjection.
No differences were observed between the two groups in the number of mature oocyte and the total cleavage rate. Oocyte survival rate, normal fertilization rate, embryos of good morphology rate and clinical pregnancy rate were significantly higher in group II than that in group I.
ICSI procedure does affect the quality of embryos. With the improvement of ICSI technique, ICSI should be the treatment of choice for male infertility and idiopathic infertility.
本研究旨在回顾性研究卵胞浆内单精子注射（ICSI）治疗男性不育症和特发性不育症的疗效。
1995年11月至1998年1月，140对夫妇（156个周期）因严重男性因素不育症或特发性不育症在我们的辅助生殖技术中心接受了ICSI治疗。治疗周期分为两组，第一组包括1997年5月之前进行的74个周期，第二组包括1997年5月之后进行的82个周期。选择成熟卵母细胞进行显微注射。
两组在成熟卵母细胞数量和总卵裂率方面未观察到差异。第二组的卵母细胞存活率、正常受精率、优质胚胎率和临床妊娠率均显著高于第一组。
ICSI操作确实会影响胚胎质量。随着ICSI技术的改进，ICSI应成为男性不育症和特发性不育症的首选治疗方法。
