Tong X, Pan W, Hong S
Central Hospital of Changning District, Shanghai 200051.
Zhonghua Fu Chan Ke Za Zhi. 1999 Mar;34(3):143-6.
To study the effect of systemic lupus erythematosus (SLE) on physical, mental development and plasma antibody level of SLE in their progenies.
Routine physical examinations of 49 children from 48 SLE mothers were conducted. Compared immuno-fluorescence anti-nuclear antibody (IFANA), anticardiolipin (ACL), extractable nuclear antigen (ENA) and anti-ds-DNA plasma levels of SLE mothers and their progenies with that levels during pregnancy and in umbilical blood.
The physical development (height and weight) in 47 out of 49 children were within normal range while the remaining 2 were in the lower limit. The autoimmune antibodies were all negative in the umbilical blood with autoimmune negative mothers, while the anti-ribonucleoprotein (anti-RNP), anti-Smith surface antigen (anti-SSA), anti-specific soluble ribonucleic acid (anti-SSB) and ACL could be transferred to fetus through placenta. During follow up study, compared the autoimmune positive rates in progenies with that of mothers, the positive rates of IFANA and anti-ds-DNA decreased significantly (P < 0.01), while no changes in ACL. Compared the autoimmune positive rates in progenies with that of their own umbilical levels, the positive rates of IFANA, anti-RNP, anti-SSA decreased significantly (P < 0.01), while no difference existed in ACL. Boys showed faster disappearance of autoimmune positive rates than that of girls.
SLE did not show significant effects on the physical development of their progenies. Most autoimmune antibodies existed in umbilical blood were transferred through placenta during pregnancy and would disappear within 9 years after birth. Autoimmune antibodies decreased quicker in boys, and it indicated that girls should be follow-up more carefully. Autoimmune antibodies in the umbilical blood is an easy method for the screening of SLE progeny.
研究系统性红斑狼疮（SLE）对其后代身体、智力发育及血浆抗体水平的影响。
对48例SLE母亲所生的49名儿童进行常规体格检查。比较SLE母亲及其后代的免疫荧光抗核抗体（IFANA）、抗心磷脂（ACL）、可提取核抗原（ENA）及抗双链DNA血浆水平与孕期及脐血中的水平。
49名儿童中47名身体发育（身高和体重）在正常范围内，其余2名处于下限。脐血中自身免疫抗体在自身免疫阴性的母亲所生婴儿中均为阴性，而抗核糖核蛋白（抗RNP）、抗史密斯表面抗原（抗SSA）、抗特异性可溶性核糖核酸（抗SSB）和ACL可通过胎盘转移至胎儿。在随访研究中，将后代的自身免疫阳性率与母亲的进行比较，IFANA和抗双链DNA的阳性率显著降低（P<0.01），而ACL无变化。将后代的自身免疫阳性率与自身脐血水平进行比较，IFANA、抗RNP、抗SSA的阳性率显著降低（P<0.01），而ACL无差异。男孩自身免疫阳性率消失速度比女孩快。
SLE对其后代的身体发育未显示出显著影响。孕期脐血中存在的大多数自身免疫抗体通过胎盘转移，出生后9年内会消失。男孩自身免疫抗体下降更快，这表明女孩应更仔细地进行随访。脐血中的自身免疫抗体是筛查SLE后代的简便方法。
