Li Y, Li M, Wu Q
Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510060.
Zhonghua Fu Chan Ke Za Zhi. 1999 Mar;34(3):162-4.
To investigate the influence of tumor size and different treatment method on the prognosis of primary vaginal malignant melanoma.
The clinical data of 25 patients with primary malignant melanoma of the vagina admitted to our hospital from Dec. 1964 to Oct. 1997 were analysed retrospectively.
The overall 2-year and 5-year survival rate were 21.4% and 5.4%, respectively. The mean survival time for patients with tumor diameter < or = 2 cm was 27.7 months and for patients with tumor > 2 cm, 9.7 months (P < 0.05). The mean survival time was 19.5 months for the 17 cases treated with surgery and 8.3 months for another 8 cases who did not received surgery (P < 0.05). Multi-variate Cox regression with tumor size, surgical treatment, chemotherapy and immunotherapy also showed that tumor diameter and surgery were significant variables statistically for survival time (both P < 0.05).
The prognosis of the primary malignant melanoma of vagina is poor and can be improved if the disease could be diagnosed early and combined modality therapy with emphasis on surgery be given.
探讨肿瘤大小及不同治疗方法对原发性阴道恶性黑色素瘤预后的影响。
回顾性分析我院1964年12月至1997年10月收治的25例原发性阴道恶性黑色素瘤患者的临床资料。
总体2年和5年生存率分别为21.4%和5.4%。肿瘤直径≤2 cm患者的平均生存时间为27.7个月，肿瘤直径>2 cm患者的平均生存时间为9.7个月（P<0.05）。17例行手术治疗患者的平均生存时间为19.5个月，8例未接受手术治疗患者的平均生存时间为8.3个月（P<0.05）。多因素Cox回归分析肿瘤大小、手术治疗、化疗和免疫治疗，结果显示肿瘤直径和手术是影响生存时间的统计学显著变量（均P<0.05）。
原发性阴道恶性黑色素瘤预后较差，若能早期诊断并给予以手术为主的综合治疗，则可改善预后。
